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![]() The iCloud is an application which allows you to save your. To return to your document in its current state without making any changes, click Done. Although often unused, the iCloud is a very powerful tool if you use multiple Apple devices. You can also copy and paste text and objects from an earlier version to the current version. Your original file is getting frequently overwritten. As in, there is no secret backup somewhere else. As a result, you can browse earlier versions, save a copy of an earlier version, or restore a document to an earlier version. In macOS, Auto Save means saving your file automatically as in, overwriting your file automatically. Restore your document to this version: Click Restore.ĭuplicate this version in a new document: Press the Option key then click Restore a Copy. Every time you save a document, Pages saves it as a new version. You can turn it off or back on and change the time period when it saves in Preferences. When you find the version you want, do one of the following: For the older AutoRecover, it is on by default. If you chose Browse All Versions, click tick marks along the timeline to browse versions. Then you can find the lost Sketch files in your backup folder. Launch Time Machine on Mac and find your latest Mac backup. ![]() Use the Spotlight to search Time Machine on Mac. Users can recover unsaved Sketch files with Mac Time Machine backup. Last Opened: All changes you made to the document since you last opened it are deleted.īrowse All Versions: The timeline for the document opens, showing tick marks on the right that indicate every time the document was opened, saved, duplicated, locked, renamed, or reverted. Top Sellers This Year High-BackArmchair 2. Time Machine is a built-in Mac backup utility. Last Saved: All changes you made to the document since you last saved it are deleted. Because Pages continually saves your work on your computer, you can browse earlier versions, restore a document to an earlier version, and create duplicate versions.Ĭhoose File > Revert To (from the File menu at the top of your computer screen), then choose one of the following: ![]() ![]() ![]() Nor do we have to remind you that practice makes perfect, and porn can show you many ways of giving and receiving sexual pleasure. We do not have to tell you that scientific research in our RedTube Labs proved that watching porn increases your fertility and a regular wank keeps you fit and healthy. Since this sex drive is in all of us and you found your way here, it is too late to pretend that you are not a wanker, such as ninety-nine percent of people are, in fact. No matter what strokes you are searching for, RedTube will satisfy the carnal sex instincts of your reptile brain. We know your need for porn, and RedTube is the shrine for your sexual salvation. Our site is dedicated to all you porno lovers out there. Enjoy before the world ends up plunged into a pandemic.Welcome to RedTube, the Home of Videos Porno. But beyond the economics class with foreign policy that you just received and that that politician who offered to lift you out of poverty you voted for will never give you, the best thing here is to delight in how hot the busty woman is. ![]() And that in Latin America you don’t see many white girls like her either.Īll that together, really. They pay for the content that we enjoy for free and thanks to the fact that there are countries where women can be whores and live with dignity, it is that we can enjoy hot blondes like her. We Third Worlders have to hope that the developed ones have something left over to see. It no longer only meets your needs for bags and shoes she also lets us see her slit for next to nothing. 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Life is beautiful when you can see a woman like Coconut Kitty naked and masturbating in a XXX video. ![]() ![]() These signals result in the activation of transcription factors such as NF-κB and AP-1, which are important in functional outcomes including IL-2 production and T cell survival. Co-stimulatory signals from the CD28 cytoplasmic tail result from interactions with a number of signaling molecules including the p85 subunit of PI3 kinase, the Src family kinase Lck, IL-2 inducible family kinase Itk, protein kinase C theta and adaptor proteins such as Grb2 and GADS 13 – 16. CD28 is the archetypal co-stimulatory molecule involved in the activation of T cells upon binding to either CD80 or CD86. Perhaps the most surprising feature of CD28 and CTLA-4 is that whilst they share the same ligands, they have opposing functions. Thus, at present, differences between the two ligands revolve mostly around different expression patterns, whereas clear functional distinctions have yet to emerge. Human peripheral blood monocytes express CD86 and not CD80, whereas some human T cells can express both CD80 and CD86 under different conditions of activation 11, 12. In contrast CD80 is thought to be upregulated later by DC. There is considerable variation in ligand expression making generalisation difficult, CD86 is often expressed constitutively on dendritic cells (DC) and is induced to high levels following inflammatory stimuli. Knockout mice show impaired immune responses consistent with reduced CD28 co-stimulation, with CD86 deficiency arguably demonstrating a more severe phenotype 9. Both ligands are found on antigen presenting cells such as dendritic cells and B cells, although they have different expression patterns, inducibility and kinetics 8 – 10. Whilst the biophysical characteristics of CD80 and CD86 are well defined, their functional differences are less clear and the ligands are often referred to together as B7 molecules or CD80/CD86. LRBA may mediate recycling of CTLA-4 to the plasma membrane, whereas AP1 may mediate CTLA-4 trafficking to lysosomal compartments resulting in subsequent degradation. LRBA and AP1 proteins have also been found to bind to the YVKM motif on CTLA-4, which appear to impose different fates on CTLA-4. The AP2 (μ2 subunit) binds to the tyrosine-based (YVKM) motif of the cytoplasmic domain of CTLA-4 and mediates rapid internalization. In the absence of the ligand, CTLA-4 is mainly found in intracellular compartments following clathrin-mediated endocytosis mediated through CTLA-4 interaction with the AP2 molecule. CTLA-4 is constitutively expressed in Treg or induced following T cell activation via CD28 and TCR signaling. ( B) CTLA-4 expressed in T-cells is highly endocytic. The relative affinities go from high to low from left to right. CTLA-4 has a higher affinity and avidity for CD80 than CD86. CD80 is a dimeric high affinity ligand and CD86 is a monomeric lower affinity ligand for both receptors. ( A) CTLA-4 and CD28 receptors share two ligands CD80 and CD86. These interactions are thought to take place at the immune synapse between T cells and APCs where CTLA-4 has been shown to recruit CD80 thereby limiting its interactions with CD28 6, 7. Amongst several possibilities, this raises the concept that CTLA-4 can compete with CD28 for ligand binding and thereby act as an antagonist of CD28-mediated co-stimulation 4, 5. CTLA-4 interacts with both ligands with higher affinity and avidity than CD28 1 – 3 with CTLA-4-CD80 forming the highest avidity interaction and CD28-CD86 the weakest ( Figure 1A). In contrast, interactions of the ligands with CTLA-4 serve to inhibit T cell responses, although the precise mechanisms are not fully understood. CD28 interacts with the CD80 dimer with relatively high affinity and the CD86 monomer with lower affinity, mediating T cell co-stimulation in conjunction with T cell receptor (TCR) signals. Both receptors share a pair of ligands expressed on the surface of antigen presenting cells (APCs). ![]() CTLA-4 and CD28 share two ligands, CD80 and CD86Ĭytotoxic T Lymphocyte antigen 4 (CTLA-4) (CD152) and CD28 are homologous receptors expressed by both CD4 + and CD8 + T cells, which mediate opposing functions in T cell activation. ![]() ![]() Maybe in some sort of base, for instance a dome with nuclear energy, humans could survive for some time. The idea that life could be sustained indefinitely without the sun is a silly dream. The gravity of Earth and the rest of the solar system would be affected and – with there being no constant energy supply from the sun – Earth would start drifting into space. If the sun was no more, then Earth would be drawn to a new centre of gravity. Planets, including Earth, would begin moving away from their usual paths and could collide with other gigantic bodies, leading to their destruction. Mahantesh Chikkadesai Bagalkot, Karnataka, Indiaĭestruction of planets would take place, because of the sudden loss of the sun’s gravitational pull. Earth’s surface air temperature has to be maintained in the vicinity of 15☌ on average for life to survive. I am more worried about cold than darkness. ![]() All of Earth would be in permanent darkness the air and oceans would retain warmth for some time, but all life would eventually freeze to via Twitter If the sun was still there, but just stopped emitting light and heat, we would stay in orbit. It depends what you mean by “disappeared”. If Earth were lucky enough to avoid getting caught up in these collisions and didn’t just fly off into space, it might start revolving around the new centre. Perhaps Jupiter, or a new giant planet formed after a collision of Jupiter with other objects that orbited the sun. Since the sun is the centre of gravity in our solar system, its disappearance would result in temporary anarchy among the remaining bodies, and after a few collisions the system may find a new centre. However, there would also be a fall in temperature that would more rapidly make survival difficult. If darkness was the only factor, it would take a while for most life to vanish from Earth. If the sun disappears suddenly, total darkness will be observed on Earth after 8 minutes – the time it take for its light to reach us. Some people could burn wood and coal for warmth, but without food we wouldn’t survive long. Some heat would filter through Earth’s crust, keeping it warmish for a time. Of course, Earth has a core of molten iron, and above that a mantle of molten rock. “Without sunshine there can be no photosynthesis. Depending on the season, we might get one last crop, or not! Our herbivores would soon chew their way through the last remaining vegetation and begin to starve. Without sunshine, there can be no photosynthesis. ![]() During the few minutes of near-darkness, the temperature fell by 4 to 5☌. The many birds flying about promptly became quiet as they settled down for the “night”. A nearby zebra herd became agitated as darkness came hours early with the sun still high in the sky. ![]() ![]() ![]() $ grafana-cli -pluginUrl grafana-cli -pluginUrl plugins install grafana-map-panel plugins install grafana-map-panel RescueTime dashboardĬopyright (C) 2022 Sam Steele. $ grafana-cli plugins install grafana-piechart-panel Most dashboards require the grafana-piechart-panel plugin, and the Foursquaure panel also requires the panodata grafana-map-panel plugin: The grafana folder contains json files for various example dashboards. Access to the Todoist API requires a premium subscription.Set MAX_POSTS to 0 to download everything. Instagram can take a very long time to download, so by default it will only fetch the 10 most recent posts.Google Play doesn't provide total play time, only achievements and last played timestamps.New data going forward will be more accurate as the script will calculate the time since the last run. Steam provides the recent playtime over 2 weeks, so the first set of data inserted will contain 2 weeks of time.RescueTime provides data each hour, so scheduling the script as an hourly cron job is recommended.Using the same database name between scripts can lead to data being unexpectedly overwritten or deleted. Each script is designed to write to its own InfluxDB database.Run each Python script from the terminal and it will insert the most recent data into InfluxDB. $ pip3 install pytz influxdb requests requests-cache instaloader trakt.py publicsuffix2 logging colorlog bs4 Install the LibreLinkUp app on your phone and accept the invitation, then set your username and password in the configuration file.Ĭheck your Python version and make sure version 3.7 or newer is installed on your system: LibreLinkUp: Open the Freestyle Libre app and choose Connected Apps from the menu, then send yourself an invite to LibreLinkUp.PSN: Link your PSN account to Exophase and then set your Exophase username and PSN nickname. ![]() Stadia: Link your Stadia account to Exophase and then set your Exophase username and Stadia nickname.Created or edit /opt/retropie/configs/all/runcommand-onstart.sh and append the line bash "/home/pi/influx-onstart.sh" Create or edit /opt/retropie/configs/all/runcommand-onend.sh and append the line bash "/home/pi/influx-onend.sh" FsHub.io: Generate a personal access token at and set your pilot ID to the number in your "Personal Dashboard" URL RetroPie: Place the shell files and python script into user pi's home directory.: Register for an API key at and generate an OAuth2 access token, you'll also need to create an API key at to download movie / show posters.GitHub: Create a personal access token at.Todoist: Access to the API requires a Todoist Premium subscription Create an app at and generate a test token.Google Play Games: Download your Google Play Games archive from and extract it in the same folder as the script.You can get your ID number by clicking your "TrueAchievement Points" score on your profile and looking at the leaderboard URL, it will be the findgamerid parameter. Xbox Live: Register a profile at and link it to your Xbox account.Nintendo Switch: You'll need to set up mitmproxy and intercept the Nintendo Switch Parent Controls app on an iOS or Android device to grab your authentication tokens and device IDs.Steam: Register for an API key at and look up your SteamID at (use the steamID64 (Dec) value).Fitbit: Register a "Personal" app at and generate an OAuth2 access token.Foursquare: Register an app at and generate an OAuth2 access token.RescueTime: Register for an API key at.Open config.py and set your API credentials and InfluxDB server configuration at the top of the file ![]() Import personal data from various APIs into InfluxDB Configuration ![]() ![]() ![]() Rithm is an incredible bootcamp and I had a great experience! The material is very relevant and constantly updating to keep up with the technology trends in the industry. Upon graduation, students receive mentorship from a career coach who can help with connections to companies requiring tech skills, including open opportunities with partner companies, including Slow Ventures network. The final weeks of the Rithm School program involves job readiness preparation and real-time practice. Rithm School will notify students if they are accepted, or suggest more study and a repeat interview. The application process is multi-step, including an online application a phone call with the Director of Admissions preparation for the technical interview using a free JavaScript prep course and a visit to the campus for the problem-solving-focused technical interview. Rithm School was founded in 2016 in San Francisco, California to provide access to a full-time accelerated learning program, with class sizes small enough to provide one-on-one instruction with instructors who have experience in both teaching and web development. Rithm School aims to help students to not only gain a deep understanding of the industry but also graduate with a portfolio of real-world projects in which they have been involved. Their curriculum is centered around JavaScript and Python, and also covers PostgreSQL, Flask, Node, Express, React, Redux, and computer science fundamentals. The Nintendo Switch launches March 3, 2017.Rithm School offers a full-time, 16-week, full stack web development immersion bootcamp in San Francisco, California and will be conducting cohorts remotely through the end of 2020. What do you think of 1-2-Switch and Arms? Are you excited to play them? Let us know in the comments. ![]() On the other hand the Nintendo Switch has games like Breath of the Wild, Xenoblade Chronicles 2, and Super Mario Odyssey for the more hardcore Nintendo gamer. Arms will not be a launch title, with Nintendo dating for a release sometime in the spring of this year.īoth Arms and 1-2-Switch seems to be catering to a more casual, party game crowd. Players will need to switch up the (titular) arms on the different fighters, which can vary the fighting style between slow but strong attacks and fast but weaker strikes. The trailer shows a face off between two players: With a combination of button presses and arm movements, players throw punches and move around the ring against their opponent. Players will need two Joy-Cons, one in each hand, to control one fighter from the roster of characters who possess spring-like extendable arms. ArmsĪrms was also announced, and is a fighting game that fits right in with Nintendo’s motion control style. The game is very reminiscent of the Wii Sports style of party game that appealed to gamers and non-gamers alike, and helped the original Nintendo Wii sell so well. Nintendo says there are “many more” games included in 1-2-Switch and that it will be a launch title for the Nintendo Switch. See also Latest Batman Rumors Have Huge Implications for Superman Game ![]() The game also includes minigames to mimic a table tennis match, a dance game that has one player striking a pose and challenging the other to match the same pose, Samurai Training that tasks one player with trying to “catch” an imaginary sword as the other brings their hands down to strike, and another that has two players squeezing and moving the Joy-Cons up and down as if milking a cow. The trailer for the game, which debuted during the Nintendo Switch Treehouse Event showed off one of the minigames included, which sets up a classic Old West duel: 1-2-Switchġ-2-Switch is being touted by Nintendo as a party game that has “players look at each other-not the screen.” Two players face each other, both using one of the included Joy-Cons, and play a variety of games that use the IR sensor and other features of the Joy-Con. Alongside details of the Switch itself, Nintendo also announced two games coming to the system that both take advantage of the console’s unique Joy-Con controller setup: 1-2-Switch and Arms. Nintendo has given many more details about the Nintendo Switch, its new console set to launch on Mafor $299.99 US. Nintendo announces two new games for the Nintendo Switch during its Treehouse event that make unique use of the Joy-Con controllers of the console, 1-2-Switch and Arms. You Are Reading : Nintendo Announces Two New Switch Games 12Switch & Arms ![]()
![]() ![]() Many firms will engage in overstocking to hedge against shortages to help them prepare for demand. It doesn’t mean the end of globalization, as some suggest, but instead a reexamining of supply chain dynamics, with a broad shift to regional manufacturing. Managing the supply chain crisis requires a range of different moves and strategic changes for manufacturers and suppliers. and Canada to assist with the needed repair or remediation of any products created in Mexico. They can also leverage the closer proximity to the U.S. And multigenerational family structures often give companies access to dedicated workforces that stay in the area.Ĭompanies moving production to Mexico can ensure optimal productivity by taking the time to understand and respect local customs and needs. In Mexico, companies have access to an established manufacturing infrastructure, as well as competitive labor costs. Mexico is a logical alternative to the challenging environment found in many Asian manufacturing centers. For example, toymaker giant Mattel announced in March 2022 a planned consolidation and expansion project in Mexico that will include a 200,000-square-foot facility and employ approximately 3,500 workers. ![]() Because of the pandemic and probably the situation in Ukraine, the supply chain that comes from Asia is moving to Mexico.” Escandon’s comments reflect robust growth in Mexico-based manufacturing, especially in areas near the U.S. Overall, the pandemic has proven that we have less resilience with just-in-time practices, with low lean inventories now driving shortages.Īs Julio Escandon, CEO of Monterrey-based lender Grupo Financiero BASE, noted in April, “It’s a year of big opportunities. Higher fuel costs and transportation capacity issues are two examples that immediately make just-in-time manufacturing more costly. The forecast’s accuracy declines in step with the length of the predictions, meaning manufacturers must abandon the standard just-in-time delivery for many market segments as it does not withstand crises. ![]() This puts enormous strain on operations leaders to assess what consumers or business partners might require several months in advance. Often the problem is not with the first tier but with the first, fourth, and fifth tiers.” His comment sheds light on the domino-effect issues with the supply chain, where limited visibility into downstream problems causes the entire system to slow to a halt.įacing long lead times due to low product availability forces companies to commit more capital further in advance. What does that mean? It basically means that a lot of companies have visibility into their first-tier suppliers-their direct suppliers-because they have a contract with them. This dynamic puts further strain on every stakeholder.Īlicke said, “The holy grail of supply-chain risk management is multitier transparency. The average cost of container rates has risen more than 500% since the pandemic began, reflecting the deep disruption for manufacturers and the higher costs and port congestion issues facing transportation firms. Higher costs drive up the price of essential products and create shortages of available products. The rising cost of logistics also complicates forecasting. Knut Alicke, a partner in McKinsey’s Stuttgart office, said, “The attention has shifted from not only being a function that is valuable when something goes wrong but can really help us to be better.” His comment points to the need for manufacturers to review and improve their supply chains through better technology. On the commercial side, if producers receive a non-conforming product, the lead time for adequate repair, replacement or remediation is more sustainable.Īccording to McKinsey, supply chain disruptions cost the average firm 45% of one year’s profits over a decade. customers creates a competitive edge with quicker delivery and installation. Shifting from Asia-based manufacturing impacts commercial markets just as much as consumers. Scott Price, president of UPS International, said that there would be “a migration to new supply chain models”-meaning goods producers will relocate existing capacity to factories closer to their consumers. Political challenges in China are driving the movement to other countries for parts. ![]() ![]() Where once you walked barefoot on dewy grass, you’re now careful to put your shoes on before venturing outside. No matter how much new seed you put down or how often you water, there will come a point where your lush green lawn turns into a crunchy brown landscape. Once dry they are best stored in an airtight container.It happens every summer. Collect stems in the morning and then use them when they are fresh or dry them by bundling a few stems together and hanging them in a dry place out of direct light. The best time to harvest the plant for these uses is after the blooming season has passed, when fresh growth has emerged. In addition to providing an attractive and aromatic ground cover, creeping thyme can be used to make tea, to flavor foods and to infuse oils and vinegars. These insects are best controlled with insecticidal soaps and Neem oil. The plant’s scent attracts helpful insects like honey bees, but is also enticing to aphids and spider mites. Impacted areas should be removed and discarded. Pests, diseases, and animalsĬreeping thyme is most vulnerable to root rot and botrytis rot, especially if it is planted in an area where drainage is less than optimal. If plants spread beyond their intended area or begin to encroach on other plants, they should be trimmed back in that area. If spent flowers are creating an unkempt appearance you can use a mower set to two or three inches high to trim the tops. ![]() In fact, cutting it back too frequently can inhibit growth and spread. PruningĬreeping thyme has a low enough profile that it does not require pruning or mowing. After a month of this gradual move, it is ready to be planted in its desired location. Within a few weeks the plant will have begun to root, at which time it is ready to be moved outdoors for short intervals until it has hardened off. Keep the cutting and soil mix in a sunny area, checking frequently to ensure that it remains moist. Then dip the cutting into rooting hormone and insert it into a hole in premoistened seed starting mix in a small container. Cut as close to the base of the stem as possible and remove the leaves from the bottom third of the stem. To divide an established plant, simply use a trowel to cut out a chunk about 4 inches deep, remove it carefully and transplant into another area with soil that has been premoistened.Īlternatively, you can take a cutting from a healthy stem of creeping thyme during its growing season. PropagationĬreeping thyme can be propagated through either division or from stem cuttings. If the soil is rich and well prepared it will not need any additional nutrients, but poor soil should be supplemented with a delayed-release fertilizer. Though the shallowness of their root system means that they can dry out easily, the plants are able to withstand dehydration once they are mature.Ĭreeping thyme’s need for fertilizer depends upon the quality of the soil in which it is planted. The soil beneath them needs to be kept moist in order to encourage their roots to get established. The creeping thyme’s greatest watering need comes when it is first planted. Placing mulch in the areas surrounding the plants is advised, though the mulch should not come into contact with the plant itself. Tamp down the earth around the plant, making sure that the roots contact the soil below.Īfter planting, the transplants and soil underneath need to be kept moist until contact and acclimation is complete. Dig a shallow hole for each new plant that is just deep enough to have its foliage level with the ground. Loosen them until a few of the rootlets are free from the tangle. If the plant is root-bound, take care when teasing the roots apart. When transplanting creeping thyme, take care not to damage its roots when you remove it from its tray or container. For creeping thyme that is being used to fill the spaces between flagstones, leave four to six inches between each plant, while creeping thyme being used as ground cover should be spaced much farther apart, at a distance of approximately 12 to 18 inches. Placement and distance between the plants depends upon the type and use. The soil where the creeping thyme is placed needs to be watered several times before planting to allow it to settle and the plants themselves should also be watered on the day that they will be transplanted. The first step before planting is to remove all weeds in the area and to level the ground, as any bumps and uneven areas will show on the surface of the ground cover. This will allow the roots to establish themselves through the growing season.Ĭreeping thyme needs soil with good drainage in order to allow the plant to flourish and spread. ![]() Planting should be done in late spring or early summer, after the fear of frost has passed. By Jo Cosgrove | Ecological Gardener, Horticulturist, and Educator – last update on December 2, 2021Ĭreeping thyme does best in an area that gets about four hours of sun a day. ![]() ![]() ![]() You can close the page and do other activities. This process can take more than 30 minutes. Please wait for the authentication process. Login using integra username and passwordĤ. Activate Office365 by clicking “Visit” on the Office365 applicationģ. Access the application page at ITS via: .id/app.phpĢ. ![]() The way to use Office365 is as follows.ġ. To be able to use O365, ITS students must first activate. Use Office legal products through Office activation.Facilitate collaboration between academics at ITS.Can download other O365 products such as Skype for Business, OneDrive for Business etc.Can download the latest version of Office offline on the office portal and activate it in an easy way.Will always be able to access the latest version of Office (Word, Excel, PPT) online.Other products such as Yammer, social media to connect with all lecturers, employees, ITS students, Calendar, OneNote, Delve, etc.īenefits of ITS Students using Office 365. ![]() One Drive (a place to store and share files through Microsoft’s Cloud service) with a capacity of 1 TB.Office online is the Office software that can be accessed online, both through the browser and mobile apps The latest version of Microsoft Office Online.Microsoft Office (Word, Excel, PPT), the latest version for Windows and OS X / macOS (Offline) and activation.Office 365 products that can be used by students include: Students can install this Office 365 product on 5 different devices. Thus, all ITS students can use the latest version of Office software and other supporting software, both online and offline. ITS provides facilities for all ITS students to get Office 365 services. ![]() |
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